HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline → 1-Benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | HCID 30024 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | 1-Benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol | HCID 177511 | 83.2% |
Reaction Steps
Treat 1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (10 g) with 48% HBr (100 mL) and heat the mixture at reflux under nitrogen for 2 h. Cool the mixture to room temperature and allow crystals to form overnight. Collect the crystals and wash with cold ethanol to give 7.5 g of the title compound as its HBr salt, mp=233°-236° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05124337 |
| Source dataset | uspto-grants-1992_06 |
| ORD ID | ord-c9e1a9cce5a54e46a15f151c95fbf8b9 |
| Source note | uspto-grants-1992_06 |