HuagongsheHuagongshe Chemistry Print Report · For research reference only
Indole → 3-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Indole | HCID 798 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 1,4-Dioxaspiro[4.5]decan-8-one | HCID 567415 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)-1H-indole | HCID 2763857 | 93.2% |
Reaction Steps
Indole (45.3 g, 0.38 mol), 1,4-cyclohexanedione monoethylene ketal (45.5 g, 0.29 mol) and potassium hydroxide (9.12 g, 0.16 mol) are heated to reflux in 100 mL of methanol for 18 hours. The reaction is cooled and the product is isolated by filtration and washed with water to give a white solid (69.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05124332 |
| Source dataset | uspto-grants-1992_06 |
| ORD ID | ord-1c78870179004eeca3cdffaf12368bf7 |
| Source note | uspto-grants-1992_06 |