Sodium Hydroxide → HCID 178420461, compound

Participants

Reaction Steps

A slurry of lithium aluminum hydride (0.472 g, 12.4 mmol) in 20 mL of tetrahydrofuran at 0° C. is treated with aluminum chloride (0.553 g, 4.15 mmol) and the mixture is stirred for 20 minutes. A slurry of trans 1-(2-{4-[1H-3-indolyl]-cyclohexyl}acetyl)-4-(2-pyridinyl)piperazine (1.67 g, 4.15 mmol) in 20 mL of tetrahydrofuran is added and the reaction is stirred at ambient temperature for 18 hours. Water (1 mL) and 10% sodium hydroxide solution (2 mL) is added the mixture is stirred for 2 hours, then filtered through celite and the volatiles are removed under reduced pressure. The resulting oil is triturated with diethyl ether to give the product as a white solid (1.57 g); mp 147°-148° C.

Provenance & Evidence