反应详情

25 ml of carbon disulfide are added to 35.2 g of 2-(4-chlorophenylmethylamino)-5-fluoroaniline, prepared in Example 8, dissolved in 500 ml of ethanol. The mixture is refluxed for 12 hours and allowed to return to room temperature. After standing for a few hours, the crystals are filtered off and washed with ethanol and then with isopropanol and ether to give 33 g of 1-(4-chlorophenylmethyl)-2-mercapto-5-fluorobenzimidazole in the form of crystals melting at 215° C.

1. customprepared in Example 8
2. temperatureThe mixture is refluxed for 12 hours
3. customto return to room temperature
4. waitAfter standing for a few hours
5. filtrationthe crystals are filtered off
6. washwashed with ethanol