4-bromo-3-(4H-1,2,4-triazol-3-yl)thiophen-2-amine → N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)-3,4-dihydroquinolin-1(2H)-yl)acetamide

HRID 89339Notes

Reaction equation

HRID 89339 reaction equation
[Br:20][c:21]1[c:22](-[c:27]2[n:28][cH:29][n:30][nH:31]2)[c:23]([NH2:26])[s:24][cH:25]1.[O:1]=[C:2]1[N:3]([CH2:16][C:17](=[O:18])[OH:19])[c:4]2[cH:5][cH:6][c:7]([C:12]([F:13])([F:14])[F:15])[cH:8][c:9]2[CH2:10][CH2:11]1>>[O:1]=[C:2]1[N:3]([CH2:16][C:17](=[O:18])[NH:26][c:23]2[c:22](-[c:27]3[n:28][cH:29][n:30][nH:31]3)[c:21]([Br:20])[cH:25][s:24]2)[c:4]2[cH:5][cH:6][c:7]([C:12]([F:13])([F:14])[F:15])[cH:8][c:9]2[CH2:10][CH2:11]1

Participants

3

Reactant 2

HCID 596366864-bromo-3-(4H-1,2,4-triazol-3-yl)thiophen-2-amineHCID 687846172-(2-Oxo-6-(trifluoromethyl)-3,4-dihydroquinolin-1(2H)-yl)acetic acid

Product 1

HCID 59636645N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)-3,4-dihydroquinolin-1(2H)-yl)acetamide

Sources & evidence

ORD record
ord-04c8bcdb2dea445cbf3d96fd37a35b1e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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