Hydrochloric Acid → 3-(Cyclopropylmethyl)-2,4-dihydroxy-N-methylbenzamide

Participants

Reaction Conditions

Reaction Steps

The compound of Example 15 (112 mg) was dissolved in about 5 to 10 ml of a 40% aqueous solution of methylamine. A few crystals of ammonium chloride were added, and the reaction mixture was stirred for about 6 hours at 50° C. The reaction mixture was neutralized with 10% hydrochloric acid and extracted with ethyl acetate. The organic layer was dried, concentrated, and chromatographed on silica gel using 15% ethyl acetate/85% hexane as eluant to give the product.

Provenance & Evidence