Lithium Hydroxide → HCID 15341828, compound

Participants

Reaction Steps

The compound of Example 49 (150 mg, 0.2769 mmol) and 1 M lithium hydroxide (554 μl, 0.5538 mmol) were added to 2.0 ml of methanol and the reaction mixture was stirred at room temperature overnight. The solvent was removed under vacuum, 2.0 ml of water was added, then the solution was acidified with 10% hydrochloric acid. The solution was extracted three times with ethyl acetate and the combined extracts were dried and filtered. The solvent was removed under vacuum to give the product as a gum.

Provenance & Evidence