HCID 15341843, compound → HCID 22399587, compound

HRID 893481Notes

Reaction equation

HRID 893481 reaction equation
[CH:1]1([CH2:4][C:5]2[C:6]([OH:15])=[C:7]([CH:11]=[CH:12][C:13]=2[OH:14])[C:8]([NH2:10])=[O:9])[CH2:3][CH2:2]1.[C:16]([O:19][CH2:20]C)(=[O:18])[CH3:17].[CH3:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]>>[NH2:10][C:8]([C:7]1[CH:11]=[CH:12][C:13]([O:14][CH2:6][CH2:7][CH2:8][O:9][C:24]2[CH:23]=[CH:22][C:27]3[CH2:4][CH2:5][CH:13]([CH2:12][CH2:17][C:16]([O:19][CH3:20])=[O:18])[O:14][C:26]=3[C:25]=2[CH2:2][CH2:1][CH3:3])=[C:5]([CH2:4][CH:1]2[CH2:3][CH2:2]2)[C:6]=1[OH:15])=[O:9]

Participants

3

Reactant 2

HCID 15341843HCID 15341843, compoundHCID 21226206Ethyl acetate hexane

Product 1

HCID 22399587HCID 22399587, compound

Procedure

The compound of Example 66 and the compound of Example 3 are coupled under the conditions outlined in Example 60. Chromatography of the crude phenolic ester on silica gel using ethyl acetate/hexane (3:7) as eluant affords the product.

Workup

  1. customaffords the product

Sources & evidence

ORD record
ord-8b987ae5599d4420a77d6b7ea7de545f
Source dataset
uspto-grants-1992_06
Patent number
US05124350

Reaction notes

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