Pyridine → N-[5-(3-chloro-4-cyano-phenyl)-pyridin-3-yl]-1-(4-fluoro-phenyl)-methanesulfonamide

HRID 89355Notes

Reaction equation

HRID 89355 reaction equation
[F:17][c:18]1[cH:19][cH:20][c:21]([CH2:24][S:25](=[O:26])(=[O:27])[Cl:28])[cH:22][cH:23]1.[NH2:1][c:2]1[cH:3][c:4](-[c:8]2[cH:9][c:10]([Cl:16])[c:11]([C:12]#[N:13])[cH:14][cH:15]2)[cH:5][n:6][cH:7]1.[cH:29]1[cH:30][cH:31][n:32][cH:33][cH:34]1>>[NH:1]([c:2]1[cH:3][c:4](-[c:8]2[cH:9][c:10]([Cl:16])[c:11]([C:12]#[N:13])[cH:14][cH:15]2)[cH:5][n:6][cH:7]1)[S:25]([CH2:24][c:21]1[cH:20][cH:19][c:18]([F:17])[cH:23][cH:22]1)(=[O:26])=[O:27]

Participants

4

Reactant 3

HCID 1049PyridineHCID 2759108(4-fluorophenyl)methanesulfonyl ChlorideHCID 595783904-(5-Amino-pyridin-3-yl)-2-chloro-benzonitrile

Product 1

HCID 49819668N-[5-(3-chloro-4-cyano-phenyl)-pyridin-3-yl]-1-(4-fluoro-phenyl)-methanesulfonamide

Sources & evidence

ORD record
ord-d7d9df1ddaca404fac417fe3a4f8ff36
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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