Water → HCID 178470130, compound

Participants

Reaction Steps

To a solution of 15.7 g of ethyl 8-chloro-6,7-difluoro-4-hydroxy-2-(methoxymethylthio)quinoline-3-carboxylate in 125 ml of 1,4-dioxane, 95 ml of 35% hydrochloric acid was added dropwise at 40° C. with stirring. The mixture was stirred at the same temperature for 1 hour. The reaction mixture was poured into 500 ml of water. The precipitate was collected by filtration and recrystallized from acetonitrile to give 11.2 g of the desired compound as pale yellow needles, m.p. 125°-130° C. (decomp.).

Provenance & Evidence