Water → HCID 54511641, compound

Participants

Reaction Steps

A mixture of 1.90 g of ethyl 8-chloro-6-fluoro-1-methyl-4-oxo-7-((S)-3-trifluoroacetylamino-1-pyrrolidinyl)-1H,4H-[1,3]-thiazeto[3,2-a]quinoline-3-carboxylate, 1.23 g of 85% potassium hydroxide, 6.0 ml of tert-butanol and 12 ml of water was stirred at room temperature for 5 hours. The reaction mixture was neutralized with aqueous acetic acid. The precipitate was collected by filtration and recrystallized from water to give 0.51 g of yellow crystals, which were consistent with that of Example 29.

Provenance & Evidence