Triethylamine → HCID 14606675, compound

Participants

Reaction Steps

To a 50 mL round bottom flask fitted with a reflux condenser was added (2R-cis)-4-aminotetrahydro-2-furanmethanol, Compound IV(f), (184 mg, 1.57 mmole), 5-amino-4,6-dichloro-pyrimidine (770 mg, 4.70 mmole), triethylamine (0.44 mL, 3.16 mmole) and t-butyl alcohol (16 mL). The reaction mixture was heated to reflux temperature under an atmosphere of argon for 72 hours, at which time the volatile materials were removed by rotary evaporation. The residue was dissolved in 100 mL EtOAc, washed with saturated NaHCO3 solution (50 mL) and saturated NaCL solution (50 mL), then dried over MgSO4. After filtration and evaporation, the product was purified by flash column chromatography (50% EtOAc/50% Hexane) to yield 220 mg (58%) of Compound IX.

Provenance & Evidence