反应详情

13 g (191 mmol) of imidazole and 1 g (9 mmol) of potassium tert. butoxide are initially introduced under a nitrogen atmosphere into 100 ml of acetonitrile under reflux and 18 g (61 mmol) of 2-(4-chlorophenyl)-2-[1-(3-chloro-1,2,4-triazol-1-yl)-cyclopropyl]-oxirane dissolved in 30 ml of acetonitrile are added dropwise. The mixture is allowed to react under reflux conditions for 10 hours and the solvent is then evaporated in vacuo. The residue is taken up in ethyl acetate and washed with water. The solution is dried over sodium sulphate and the solvent is removed in vacuo. Chromatographic purification on silica gel (solvent: dichloromethane/ethanol=90/10) gives 7.1 g (32% of theory) of the title compound of m.p. 231° C.

1. temperatureunder reflux
2. additionare added dropwise
3. customto react under reflux conditions for 10 hours
4. customthe solvent is then evaporated in vacuo
5. washwashed with water
6. dry with materialThe solution is dried over sodium sulphate
7. customthe solvent is removed in vacuo
8. customChromatographic purification on silica gel (solvent: dichloromethane/ethanol=90/10)