Chloroacetyl chloride → HCID 19756204, compound

HRID 893651Notes

Reaction equation

[CH2:1]([C:3]1[CH2:4][NH:5][C:6]2[N:7]([N:19]=[CH:20][C:21]=2[C:22]#[N:23])[C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=1)[CH3:2].[Cl:24][CH2:25][C:26](Cl)=[O:27]>>[Cl:24][CH2:25][C:26]([N:5]1[CH2:4][C:3]([CH2:1][CH3:2])=[C:8]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=2)[N:7]2[N:19]=[CH:20][C:21]([C:22]#[N:23])=[C:6]12)=[O:27]

Participants

Reactant 2

HCID 6577Chloroacetyl chloride

HCID 136117614HCID 136117614, compound

Product 1

HCID 19756204HCID 19756204, compound

Procedure

The reactants were prepared as follows. Using the method of Example 2, 4,5-dihydro-6-ethyl-7 -[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitrile was reacted with chloroacetyl chloride to give 4-(chloroacetyl)-4,5-dihydro-6-ethyl-7-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitrile, m.p. 150°-152° C.

Workup

customThe reactants were prepared

Sources & evidence

ORD record: ord-3801f46c643749b29fc8819037eb019e
Source dataset: uspto-grants-1992_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05126340

Reaction notes

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