HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → 4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethylnaphth-2-yl)ethynyl]-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Benzonitrile, 4-bromo- | HCID 12162 | — |
| Reactant | 1,1,4,4-Tetramethyl-6-ethynyl-1,2,3,4-tetrahydronaphthalene | HCID 14726549 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethylnaphth-2-yl)ethynyl]-benzonitrile | HCID 13604826 | — |
Reaction Steps
A mixture of 4 g (19 millimoles) of (5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphth-2-yl)-ethyne, 2.8 g (12.5 millimoles) of 4-bromobenzonitrile, 50 mg of palladium (II) acetate, 100 mg of triphenylphosphine and 25 ml of degased anhydrous triethylamine was refluxed for 4 hours under nitrogen. Thereafter, solid material was filtered off and the filtrate was evaporated down.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05126371 |
| Source dataset | uspto-grants-1992_06 |
| ORD ID | ord-d5d9a3d9713349b2ba35ed4b188b6efd |
| Source note | uspto-grants-1992_06 |