HCID 141560620, compound → HCID 88496648, compound

Participants

Reaction Steps

Diphenylmethyl 7-[(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido]-3-[(E)-(5,6-dihydroxybenzimidazol-1-yl)-1-propen-1-yl]-3-cephem-4-carboxylate (XIb) (125 mg was dissolved in trifluoroacetic acid (TFA, 1.2 ml), stirred at room temperature for an hour and diluted with isopropyl ether to precipitate 63 mg of a crude product. The product was chromatographed on a column of Prep C18 (Waters) with water and 5% acetonitrile in water as eluants. The desired fractions, checked by HPLC*, were combined, concentrated to a small volume and freeze-dried to afford 7 mg (13% yield) of the title compound.

Provenance & Evidence