Butyl isocyanate → HCID 57238985, compound

HRID 893789Notes

Reaction equation

[CH2:1]([N:5]=[C:6]=[O:7])[CH2:2][CH2:3][CH3:4].[Cl:8][C:9]1[N:14]=[C:13]([NH2:15])[N:12]=[C:11]([NH2:16])[CH:10]=1>>[NH2:15][C:13]1[N:12]=[C:11]([NH:16][C:6]([NH:5][CH2:1][CH2:2][CH2:3][CH3:4])=[O:7])[CH:10]=[C:9]([Cl:8])[N:14]=1

Participants

Reactant 2

HCID 8110Butyl isocyanate

HCID 674322,4-Diamino-6-chloropyrimidine

Product 1

HCID 57238985HCID 57238985, compound

Conditions

Temperature: 80 °C

Procedure

8.6 cm3 butylisocyanate was added to a suspension of 5 g 6-chloro-2,4-diaminopyrimidine in 50 cm3DMSO. The reaction medium was maintained at 80° C. until it was shown by TLC that the starting compound had disappeared.

Sources & evidence

ORD record: ord-4ea97e5c10884feab2550fd1da5f75c4
Source dataset: uspto-grants-1992_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05126453

Reaction notes

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