HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl acetoacetate → Nifedipine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | 2-Nitrobenzaldehyde | HCID 11101 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Product | Nifedipine | HCID 4485 | 80.5% |
Reaction Steps
One proceeds as described in Example 7 except that 0.4 mole of 2-nitro-benzaldehyde, 0.8 mole of a 25% aqueous ammonium hydroxide solution and 0.88 mole of methyl acetoacetate are used. Thus 111.4 g of nifedipine are obtained, yield 80.5%. The product complies with the requirements of USP XXI without further purification. M. p.: 172°-175° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05126457 |
| Source dataset | uspto-grants-1992_06 |
| ORD ID | ord-dfec5e5f6fbe410d9f13ad8f443ac468 |
| Source note | uspto-grants-1992_06 |