HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl acetoacetate → Nifedipine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | 2-Nitrobenzaldehyde | HCID 11101 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Product | Nifedipine | HCID 4485 | 81% |
Reaction Steps
One proceeds as described in Example 7 except that 0.4 mole of 2-nitro-benzaldehyde, 0.415 mole of a 25% aqueous ammonium hydroxide solution and 1.40 moles of methyl acetoacetate are used. Thus 112.1 g of nifedipine are obtained, yield 81%, m.p.: 172°-175° C. The product complies with the requirements of USP XXI without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05126457 |
| Source dataset | uspto-grants-1992_06 |
| ORD ID | ord-6916f565fb9948ff8ce2084ff9af461f |
| Source note | uspto-grants-1992_06 |