Sodium Methoxide → HCID 178496816, compound

HRID 893800Notes

Reaction equation

HRID 893800 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]=[C:4]([NH:9][C:10](=[NH:13])[O:11][CH3:12])[N:3]=1.[CH3:14][O-:15].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[C:6]([O:15][CH3:14])[N:5]=[C:4]([NH:9][C:10](=[NH:13])[O:11][CH3:12])[N:3]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 178496815HCID 178496815, compound

Product 1

HCID 178496816HCID 178496816, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

9.1 g (0.041 mol) of N-(4,6-dichloro-pyrimidin2-yl)-O-methyl-isourea are initially introduced in 80 ml of methanol. 2.2 g of sodium methoxide (0.041 mol), dissolved in 20 ml of methanol, are then added dropwise at 20° C. The mixture is subsequently stirred for 12 hours and concentrated, the residue is taken up in methylene chloride, and the solution is washed three times with water and concentrated again. 7.6 g (86% of theory) of N-(4-chloro-6-methoxy-pyrimidin-2-yl) -O-methyl-isourea are obtained in the form of white crystals of melting point 118°-120° C.

Workup

  1. additionare then added dropwise at 20° C
  2. concentrationconcentrated
  3. washthe solution is washed three times with water
  4. concentrationconcentrated again

Sources & evidence

ORD record
ord-42bd3eb5572043c989f3fcd76d5ce794
Source dataset
uspto-grants-1992_06
Patent number
US05126454

Reaction notes

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