Potassium Hydroxide → HCID 14574099, compound

HRID 893813Notes

Reaction equation

HRID 893813 reaction equation
[OH:1][CH2:2][CH2:3][N:4]([CH2:17][CH2:18][OH:19])[C:5](=[O:16])[C:6]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[CH:9]=[CH:8][C:7]=1Cl.[OH-].[K+]>O>[N+:12]([C:10]1[CH:9]=[CH:8][C:7]2[O:1][CH2:2][CH2:3][N:4]([CH2:17][CH2:18][OH:19])[C:5](=[O:16])[C:6]=2[CH:11]=1)([O-:14])=[O:13]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 19891362HCID 19891362, compound

Product 1

HCID 14574099HCID 14574099, compoundYield 66.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
10 °C

Procedure

144.5 g of N,N-bis(2-hydroxyethyl)-2-chloro-5-nitrobenzamide in 500 ml of water containing 28 g of potassium hydroxide are heated for 2 hours with reflux cooling. The mixture is cooled to 10° C. and the precipitated, single-substance product is filtered off with suction and dried. 84 g of 7-nitro-4-(2-hydroxyethyl)-2,3-dihydro-1,4-benzoxazepin-5-one of melting point 151° C. are obtained. ##STR22##

Workup

  1. temperaturewith reflux
  2. temperaturecooling
  3. filtrationthe precipitated, single-substance product is filtered off with suction
  4. customdried

Sources & evidence

ORD record
ord-11ae5788d12749a39038a3be7bae2240
Source dataset
uspto-grants-1992_06
Patent number
US05126481

Reaction notes

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