Hydrochloric Acid → HCID 53799528, compound

Participants

Reaction Steps

In 10 ml of anhydrous ether was dissolved 1.4 g (5.1 mmol) of (S)-(+)-2-fluoro-2-(trifluoromethyl)decanoyl chloride, and then 0.14 g (3.5 mmol) of lithium aluminum hydride was portion-wise added to the above-obtained solution while the solution was being cooled with ice. The resulting mixture was stirred for 3 hours. Thereafter, 1N hydrochloric acid was portionwise added to the resulting reaction mixture while the mixture was being cooled with ice, and then a reaction product was extracted with ether. The resulting ether layer was dried with magnesium sulfate, the solvent was removed under reduced pressure, and then the residual product was distilled. Thus, there was obtained 0.69 g of (R)-(-)-2-fluoro-2-(trifluoromethyl)-1-decanol having the physical properties as mentioned hereinbefore, in a yield of 56%.

Provenance & Evidence