HCID 14423281, compound → HCID 14423289, compound

Participants

Reaction Steps

Oxidize 10-(3-chlorophenyl)-6,7,8,9-tetrahydropyrido[2,3-b] [1,6]naphthyridin-5(10H)-one (1.6 mmol) in a refluxing solution of xylene (15 ml), using air as the oxidant and 5% Pd on C (15 mg) as the catalyst. Follow the procedure of Tetrahedron Letters26, 1259-1260 (1985); pass air through the hot solution for 15 hours. Evaporate the xylene and elute the residue from silica gel with chloroform to provide 10-(3-chlorophenyl)pyrido[2,3-b] [1,6]naphthyridin-5(10H)-one, m.p. 222°-224° C. after crystallization from CH3Cl/pet. ether.

Provenance & Evidence