Ethyl nitroacetate → HCID 14994411, compound

Participants

Reaction Conditions

Reaction Steps

In 50 ml of dry xylene were dissolved 10.97 g of (benzo[b]thiophen-3-ylmethyl)isopropylamine and 13.3 g of ethyl nitroacetate and the temperature of the solution was raised to 100° C. with stirring under nitrogen gas stream. After 5 hours. insoluble matter was filtered off, the solvent was distilled off under reduced pressure from the filtrate, and the residue was dissolved in 500 ml of ethyl acetate. The solution was washed thrice with 100 ml of an aqueous 5% citric acid solution, thrice with 100 ml of an aqueous 5% sodium hydrogencarbonate solution, and then twice with 100 ml of a saturated aqueous sodium chloride solution and after drying with sodium sulfate, ethyl acetate was distilled off under reduced pressure from the solution. After removing excess ethyl nitroacetate by means of a vacuum pump, the residue was subjected to silica gel column chromatography to provide 11.17 g (yield of 80%) of 3-(benzo[b]thiophen-3-yl)-2-nitropropionic acid ethyl ester.

Provenance & Evidence