Ammonia → HCID 19891229, compound

HRID 893864Notes

Reaction equation

HRID 893864 reaction equation
C([O:3][C:4]([C:6]1[CH2:7][S:8][C:9]23[CH:18]=[CH:17][CH:16]=[CH:15][C:10]2=[N:11][CH:12]=[CH:13][C:14]=13)=O)C.[NH3:19]>C(O)C>[S:8]1[C:9]23[CH:18]=[CH:17][CH:16]=[CH:15][C:10]2=[N:11][CH:12]=[CH:13][C:14]3=[C:6]([C:4]([NH2:19])=[O:3])[CH2:7]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 69959905HCID 69959905, compound

Product 1

HCID 19891229HCID 19891229, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 30 ml of ethanol was dissolved 487 mg of benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester and ammonia gas was slowly blown into the solution for 15 minutes under ice-cooling. After allowing the solution to stand for 3 days at room temperature, crystals thus deposited were collected by filtration to provide 410 mg (yield of 89%) of benzo[b]thieno[2,3-c]pyridine-3-carboamide.

Workup

  1. temperaturecooling
  2. waitto stand for 3 days at room temperature
  3. filtrationcrystals thus deposited were collected by filtration

Sources & evidence

ORD record
ord-c09f3c3bab624fa196c0d49ad5c32930
Source dataset
uspto-grants-1992_06
Patent number
US05126448

Reaction notes

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