反应详情

A mixture of N-amino-phthalimide (50 g) and 2,5-hexadione (35.2 g) in 400 ml acetic acid was refluxed for 48 hours, stripped of solvent, slurried in methylene chloride and filtered. The filtrate was washed with saturated sodium bicarbonate solution, dried and stripped to yield N-(2,5-dimethylpyrrol-1-yl)-phthalimide (98%).

1. temperaturewas refluxed for 48 hours
2. filtrationfiltered
3. washThe filtrate was washed with saturated sodium bicarbonate solution
4. customdried