Pyridine → HCID 12800072, compound

Participants

Reaction Steps

The product of Example 1 (13.2 g) and pyridine (9.48 g) were stirred in ethyl acetate (200 ml) at room temperature with dropwise addition of 13.56 g chloroacetyl chloride. The mixture was stirred overnight, stripped, dissolved in methylene chloride, washed with water, dried and stripped. The residue was chromatographed in a silica gel (325 g) column (chloroform elution), to yield the title product (12.27 g).

Provenance & Evidence