Morpholine → 2-(Morpholin-4-yl)-1-(4-nitrophenyl)ethan-1-one

HRID 893924Notes

Reaction equation

[N+:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8](=[O:11])[CH2:9]Br)=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>>[N+:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8](=[O:11])[CH2:9][N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

Reactant 2

HCID 8083Morpholine

HCID 668402-Bromo-4'-nitroacetophenone

Product 1

HCID 2297452-(Morpholin-4-yl)-1-(4-nitrophenyl)ethan-1-one

Procedure

Reaction of 4-nitrophenacyl bromide with morpholine affords the novel intermediate 1-(4-nitrophenyl)-2-morpholinylethanone which when reduced yields the novel sunscreen 1-(4-aminophenyl)-2-morpholinylethanone.

Sources & evidence

ORD record: ord-bc4849863db14a0481b4e8f733113b9a
Source dataset: uspto-grants-1981_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04282206

Reaction notes

Loading…