Morpholine → 2-(Morpholin-4-yl)-1-(4-nitrophenyl)ethan-1-one

HRID 893925Notes

Reaction equation

HRID 893925 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8](=[O:11])[CH2:9]Br)=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>>[NH2:1][C:4]1[CH:13]=[CH:12][C:7]([C:8](=[O:11])[CH2:9][N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[CH:6][CH:5]=1.[N+:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8](=[O:11])[CH2:9][N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 668402-Bromo-4'-nitroacetophenone

Product 2

HCID 2297452-(Morpholin-4-yl)-1-(4-nitrophenyl)ethan-1-oneHCID 6488230HCID 6488230, compound

Procedure

The compound of the present invention (I) is prepared by reacting 4-nitrophenacyl bromide with morpholine to produce the intermediate 1-(4-nitrophenyl)-2-morpholinylethanone (II) which is reduced to produce 1-(4-aminophenyl)- 2-morpholinylethanone (I). ##STR2##

Sources & evidence

ORD record
ord-fa61bf9aebc6437092e8695517bf9ec3
Source dataset
uspto-grants-1981_08
Patent number
US04282206

Reaction notes

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