Ethanol → HCID 178468473, compound

HRID 893939Notes

Reaction equation

HRID 893939 reaction equation
[S:1]=[C:2]1[N:11]2[N:12]=[C:13]([C:15]([OH:17])=[O:16])[CH:14]=[C:10]2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[NH:3]1.P(Cl)(Cl)(Cl)(Cl)Cl.N1C=CC=[CH:26][CH:25]=1.C(O)C>C(Cl)Cl>[S:1]=[C:2]1[N:11]2[N:12]=[C:13]([C:15]([O:17][CH2:25][CH3:26])=[O:16])[CH:14]=[C:10]2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[NH:3]1

Participants

6

Reactant 4

HCID 702EthanolHCID 1049PyridineHCID 24819Phosphorus pentachlorideHCID 178524019HCID 178524019, compound

Product 1

HCID 178468473HCID 178468473, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.5 g (0.006 mole) of 5,6-dihydro-5-thioxopyrazolo-[1,5-c]quinazoline-2-carboxylic acid (prepared as described in Example 1) and 1.26 g (1 equivalent) of phosphorus pentachloride are heated together in 50 ml of methylene chloride at 60° for 30 minutes. The reaction mixture is cooled and the solvent stripped off and replaced with 50 ml of dry pyridine. The solution is treated with 1.1 ml of absolute ethanol and refluxed under N2 for 2 hours.

Workup

  1. temperatureThe reaction mixture is cooled
  2. temperaturerefluxed under N2 for 2 hours

Sources & evidence

ORD record
ord-6b879f9c66c24a70b7eb71ccde2f3774
Source dataset
uspto-grants-1981_08
Patent number
US04282226

Reaction notes

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