Diisobutylaluminumhydride → HCID 178519262, compound

HRID 893940Notes

Reaction equation

HRID 893940 reaction equation
C([O:3][C:4]([C:6]1[CH:18]=[C:17]2[N:8]([C:9](=[S:19])[NH:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=32)[N:7]=1)=O)C.[H-].C([Al+]CC(C)C)C(C)C>ClCCl>[OH:3][CH2:4][C:6]1[CH:18]=[C:17]2[N:8]([C:9](=[S:19])[NH:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=32)[N:7]=1

Participants

4

Reactant 2

HCID 21225700Diisobutylaluminumhydride2×HCID 178468473HCID 178468473, compound

Product 1

HCID 178519262HCID 178519262, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.37 g (0.005 mole) of 5,6-dihydro-5-thioxopyrazolo-[1,5-c]quinazoline-2-carboxylic acid ethyl ester prepared as described in Example 2 is suspended in 100 ml of dichloromethane and treated with 8 ml (0.011 mole) of 20% diisobutylaluminum hydride (Dibal). The resultant yellow solution is stirred at room temperature for 45 minutes, 2.0 ml (0.003 M) of Dibal solution is added and stirring continued for 17 hours.

Workup

  1. stirringstirring
  2. waitcontinued for 17 hours

Sources & evidence

ORD record
ord-733ff60d60644129aa9f4ee6f59c07ce
Source dataset
uspto-grants-1981_08
Patent number
US04282226

Reaction notes

Loading…