2-Isopropyl-2,5-diazabicyclo[2.2.1]heptane → 5-bromo-1-(2,6-dichlorophenyl)-7-[(5-isopropyl-2,5-diazabicyclo[2.2.1]hept-2-yl)methyl]-3-(4-methoxybenzyl)-3,4-dihydroquinazolin-2(1H)-one

HRID 89395Notes

Reaction equation

HRID 89395 reaction equation
[Br:1][c:2]1[c:3]2[c:8]([cH:9][c:10]([CH:12]=[O:13])[cH:11]1)[N:7]([c:14]1[c:15]([Cl:21])[cH:16][cH:17][cH:18][c:19]1[Cl:20])[C:6](=[O:22])[N:5]([CH2:23][c:24]1[cH:25][cH:26][c:27]([O:30][CH3:31])[cH:28][cH:29]1)[CH2:4]2.[CH:32]([CH3:33])([CH3:34])[N:35]1[CH:36]2[CH2:37][NH:38][CH:39]([CH2:40]1)[CH2:41]2>>[Br:1][c:2]1[c:3]2[c:8]([cH:9][c:10]([CH2:12][N:38]3[CH2:37][CH:36]4[N:35]([CH:32]([CH3:33])[CH3:34])[CH2:40][CH:39]3[CH2:41]4)[cH:11]1)[N:7]([c:14]1[c:15]([Cl:21])[cH:16][cH:17][cH:18][c:19]1[Cl:20])[C:6](=[O:22])[N:5]([CH2:23][c:24]1[cH:25][cH:26][c:27]([O:30][CH3:31])[cH:28][cH:29]1)[CH2:4]2

Participants

3

Reactant 2

HCID 226479002-Isopropyl-2,5-diazabicyclo[2.2.1]heptaneHCID 226479545-Bromo-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydroquinazoline-7-carbaldehyde

Product 1

HCID 226481855-bromo-1-(2,6-dichlorophenyl)-7-[(5-isopropyl-2,5-diazabicyclo[2.2.1]hept-2-yl)methyl]-3-(4-methoxybenzyl)-3,4-dihydroquinazolin-2(1H)-one

Sources & evidence

ORD record
ord-313fd646daa34ebaa2bc0b17729a806c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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