反应详情

A solution of 1.61 g. 2-cyanoaziridine in 30 ml. toluene is added dropwise at 20° to 30° C. to a solution of 3 g. trimethyl-acetyl isocyanate in 40 ml. anhydrous toluene and the reaction mixture then stirred for 1 hour at ambient temperature, whereafter the milky solution obtained is evaporated in a vacuum. The evaporation residue is rubbed with a glass rod until crystallization commences and the crystals obtained are triturated with diethyl ether. There is thus obtained 1.82 g. 1-(N-pivaloyl-carbamoyl)-2-cyanoaziridine which, after drying at 60° C. in a vacuum, melts at 136°-138° C.

1. customobtained
2. customis evaporated in a vacuum
3. customThe evaporation residue is rubbed with a glass rod until crystallization commences
4. customthe crystals obtained
5. customare triturated with diethyl ether
6. dry with material1-(N-pivaloyl-carbamoyl)-2-cyanoaziridine which, after drying at 60° C. in a vacuum, melts at 136°-138° C.