Chloroacetyl isocyanate → HCID 21161936, compound

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Reaction Steps

1 g. Crude 2-cyano-3-phenyl-aziridine is dissolved in 25 ml. anhydrous diethyl ether. A solution of 0.83 g. chloroacetyl isocyanate in 3.5 ml. diethyl ether is added thereto dropwise, while stirring, and the reaction mixture is further stirred for 1 hour at ambient temperature. The precipitate obtained is then filtered off with suction, washed with diethyl ether and dried in a vacuum. There is thus obtained 1.24 g. 1-(N-chloroacetyl-carbamoyl)-2-cyano3-phenyl-aziridine; m.p. 153°-158°-165° C. According to the NMR spectrum, the product is an isomeric mixture containing about 30% of the trans form and about 70% of the cis form.

Provenance & Evidence