Diethyl Ether → HCID 88769929, compound

HRID 893965Notes

Reaction equation

HRID 893965 reaction equation
[CH3:1][O:2][P:3]([N:7]=[C:8]=O)([O:5][CH3:6])=[O:4].[C:10]([CH:12]1[CH2:14][NH:13]1)#[N:11].C([O:17]CC)C>>[CH3:6][O:5][P:3]([N:7]1[CH2:8][C:12]1([C:14](=[O:17])[NH2:13])[C:10]#[N:11])([O:2][CH3:1])=[O:4]

Participants

4

Reactant 3

HCID 3283Diethyl Ether2×HCID 118115Aziridine-2-carbonitrileHCID 15570682HCID 15570682, compound

Product 1

HCID 88769929HCID 88769929, compound

Procedure

A solution of 3.6 g. dimethoxyphosphoryl isocyanate in 18 ml. anhydrous diethyl ether is added dropwise at 5°-10° C. to a solution of 1.62 g. 2-cyanoaziridine in 36 ml. anhydrous diethyl ether. After stirring for 2 hours in an ice bath, the reaction mixture is allowed to warm to ambient temperature. The precipitated crystals are filtered off with suction and washed with diethyl ether. There is thus obtained 1.85 g. 1-N-dimethoxyphosphoryl-carbamoyl-2-cyanoaziridine; m.p. 72°-76° C. (decomp.).

Workup

  1. filtrationThe precipitated crystals are filtered off with suction
  2. washwashed with diethyl ether

Sources & evidence

ORD record
ord-227f172474b14ebd9b0c93106f90f561
Source dataset
uspto-grants-1981_08
Patent number
US04282212

Reaction notes

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