Hydrochloric Acid → HCID 131712307, compound

Participants

Reaction Steps

8.7 g of 4-bromomethyl-2,6-dichloroquinoline (0.03 mol), 7.7 g of 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol (0.03 mol), 30 g of sodium hydroxide (0.75 mol) dissolved in 30 ml water, 0.5 g of benzyltrimethylammonium chloride and 100 ml of tetrahydrofuran are reacted as described in Example 1. Work up of the mixture results in an oil, which after treatment in boiling ether, is dissolved in 250 ml of ethyl acetate. To the charcoaled solution is added etheral hydrochloric acid. The precipitated hydrochloride is filtered off, washed with ethyl acetate, treated with boiling acetonitrile and finally with anhydrous ether. Yield 4.9 g (32.6%); m.p. 192°-194° C.

Provenance & Evidence