HCID 135580970, compound → HCID 178433677, compound

HRID 893985Notes

Reaction equation

HRID 893985 reaction equation
[SH:1][C:2]1[CH:12]=[CH:11][C:5]([C:6](=[NH:10])OCC)=[CH:4][CH:3]=1.[CH3:13][C:14]1[N:15]=[CH:16][NH:17][C:18]=1[CH2:19][S:20][CH2:21][CH2:22][NH2:23]>C(O)C>[CH3:13][C:14]1[NH:15][CH:16]=[N:17][C:18]=1[CH2:19][S:20][CH2:21][CH2:22][NH:23][C:6](=[NH:10])[C:5]1[CH:4]=[CH:3][C:2]([SH:1])=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 135580970HCID 135580970, compoundHCID 178433288HCID 178433288, compound

Product 1

HCID 178433677HCID 178433677, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-Cyanothiophenol was treated with hydrogen chloride in ether at 0° and the hydrochloride salt produced was treated with potassium carbonate to give ethyl 4-mercaptobenzimidate. Ethyl 4-mercaptobenzimidate was treated with 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole in dry ethanol at room temperature to give the title product.

Sources & evidence

ORD record
ord-b0964a38c0bb4b4fa1cbfe83726b19db
Source dataset
uspto-grants-1981_08
Patent number
US04282234

Reaction notes

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