Acetic Acid → HCID 12895870, compound

Participants

Reaction Steps

A mixture of 130 mg of 2-(10,11-dihydro-8-methoxy-11-oxodibenzo[b,f]thiepin-2-yl)-propionamide, 20 ml of hydrobromic acid and 8 ml of acetic acid was refluxed with stirring for 3 hours. The solvent was distilled off to obtain a residue, which was extracted with chloroform. The extract was washed with a saturated sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was distilled off to obtain crude crystals, which were recrystallized from ethyl acetate--n-hexane to obtain 102 mg (yield: 82%) of 2-(10,11-dihydro-8-hydroxy-11-oxodibenzo[b,f]thiepin-2-yl)-propionic acid as a light yellow powder having a melting point of 216°-217° C.

Provenance & Evidence