Ethanol → HCID 21162417, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 180 mg of 2-(10,11-dihydro-9-methoxy-11-oxodibenzo[b,f]thiepin-2-yl)-propionamide and 5 ml of ethanol was added 700 mg of potassium hydroxide in 5 ml of water, and the resulting mixture was stirred at 75° C. for 1 hour and further at 85° C. for 2 hours. The solvent or ethanol was removed by distillation to obtain a mixture, to which was added water, and the resulting mixture washed with chloroform. The aqueous layer was acidified with hydrochloric acid and extracted with ethyl acetate. The extract was washed with a saturated sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was distilled off to obtain a red oily substance, which was chromatographed over 3 g of silica gel and eluted with chloroform, thereby obtaining 48 mg (yield: 27%) of 2-(10,11-dihydro-9-methoxy-11-oxodibenzo[b,f]thiepin-2-yl)-propionic acid as a yellow oily substance.

Provenance & Evidence