HCID 21162409, compound → HCID 21162411, compound

Participants

Reaction Steps

To a mixture of 40 mg of methyl 2-(10,11-dihydro-8-nitro-11-oxodibenzo[b,f]thiepin-2-yl)-propionate and 3 ml of acetone was added a small amount of 10% palladium carbon, and the resulting mixture was subjected to catalytic reduction. The reaction mixture was filtrated with a suction using cerite to remove the catalysts. The solvent was removed by distillation to obtain a yellow oil, which was chromatographed over 2 g of silica gel and eluted with chloroform, thereby obtaining 13 mg (yield: 36%) of methyl 2-(8-amino-10,11-dihydro-11-oxodibenzo[b,f]thiepin-2-yl)-propionate as a yellow oil.

Provenance & Evidence