Trichloroacetyl chloride → 2-Phenylthio-5-trichloroacetylpyrrole

HRID 894042Notes

Reaction equation

HRID 894042 reaction equation
[C:1]1([S:7][C:8]2[NH:9][CH:10]=[CH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:13][C:14]([Cl:19])([Cl:18])[C:15](Cl)=[O:16]>C(Cl)Cl>[C:1]1([S:7][C:8]2[NH:9][C:10]([C:15](=[O:16])[C:14]([Cl:19])([Cl:18])[Cl:13])=[CH:11][CH:12]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 6420Trichloroacetyl chlorideHCID 127893912-Phenylthiopyrrole

Product 1

HCID 204009762-Phenylthio-5-trichloroacetylpyrrole

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-Phenylthiopyrrole (1.75 g., 10 mmoles) was dissolved in 20 ml. of methylene chloride. Trichloroacetyl chloride (1.1 ml., 10 mmoles) was added and the reaction stirred for 3 hours at room temperature. The reaction mixture was washed with 20 ml. of water and concentrated to yield 2-phenylthio-5-trichloroacetylpyrrole, used directly in the next step.

Workup

  1. washThe reaction mixture was washed with 20 ml
  2. concentrationof water and concentrated

Sources & evidence

ORD record
ord-afaac6045fa84aaa8ebbff875492f882
Source dataset
uspto-grants-1981_08
Patent number
US04282242

Reaction notes

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