3,5-Dimethoxybenzoyl chloride → HCID 13064272, compound

HRID 894054Notes

Reaction equation

HRID 894054 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([O:12][CH3:13])[CH:11]=1)[C:6](Cl)=[O:7].[NH:14]1[CH:18]=[CH:17][C:16]([C:19]([O:21][CH3:22])=[O:20])=[CH:15]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([O:12][CH3:13])[CH:11]=1)[C:6]([C:18]1[NH:14][CH:15]=[C:16]([C:19]([O:21][CH3:22])=[O:20])[CH:17]=1)=[O:7]

Participants

3

Reactant 2

HCID 870033,5-Dimethoxybenzoyl chlorideHCID 12361759methyl 1H-pyrrole-3-carboxylate

Product 1

HCID 13064272HCID 13064272, compound

Procedure

By the procedure of Example 64, but a 5 hour reaction time, 3,5-dimethoxybenzoyl chloride (4.0 g., 20 mmoles) was reacted with methyl pyrrole-3-carboxylate to yield, without recrystallization, methyl 5-(3,5-dimethoxybenzoyl)pyrrole-3-carboxylate (3.7 g., m.p. 115°-120° C., m/e 289).

Sources & evidence

ORD record
ord-ecbaceb85da3466796e7748f6ca36da6
Source dataset
uspto-grants-1981_08
Patent number
US04282242

Reaction notes

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