Methanol → HCID 13064274, compound

HRID 894055Notes

Reaction equation

HRID 894055 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:17]=[CH:18][C:19]=1OC)[C:6]([C:8]1[NH:12][CH:11]=[C:10]([C:13]([O:15]C)=[O:14])[CH:9]=1)=[O:7].[OH-:22].[Na+].[CH3:24]O>>[CH3:24][O:22][C:18]1[CH:17]=[C:5]([CH:4]=[C:3]([O:2][CH3:1])[CH:19]=1)[C:6]([C:8]1[NH:12][CH:11]=[C:10]([C:13]([OH:15])=[O:14])[CH:9]=1)=[O:7]

Participants

4

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 20400872HCID 20400872, compound

Product 1

HCID 13064274HCID 13064274, compound

Procedure

Methyl 5-(3,4-dimethoxybenzoyl)pyrrole-3-carboxylate (3.7 g.) was refluxed with 40 ml. of methanol and 40 ml. of 1 N sodium hydroxide for 2 hours and isolated by the procedure of Example 73. Recrystallization from methanol gave purified 5-(3,5-dimethoxybenzoyl)pyrrole-3-carboxylic acid (1.5 g., m.p. 267°-269° C.).

Workup

  1. customisolated by the procedure of Example 73
  2. customRecrystallization from methanol
  3. customgave
  4. custompurified 5-(3,5-dimethoxybenzoyl)pyrrole-3-carboxylic acid (1.5 g., m.p. 267°-269° C.)

Sources & evidence

ORD record
ord-033066a6794949d886a363bb77555b94
Source dataset
uspto-grants-1981_08
Patent number
US04282242

Reaction notes

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