反应详情

2-(4-Chlorophenyl)-3-carbethoxymethylaminoacrylaldehyde (73.6 g.) was refluxed in 300 ml. of ethylene glycol for 10 minutes. The reaction mixture was cooled, diluted with 1 liter of water, product extracted into chloroform, treated with activated carbon and evaporated to solids. Trituration with ether gave crude product (8 g.). An additional quantity of crude product (7.5 g.) crystallized from the aqueous phase which had been standing. Recrystallization of the combined crude solids from chloroform gave 2-hydroxyethyl 4-(4-chlorophenyl)pyrrole-2-carboxylate (5 g., m.p. 128°-130° C.). The ether and chloroform mother liquors were combined and evaporated to yield an additional 40 g. of crude product.

1. temperatureThe reaction mixture was cooled
2. extractionextracted into chloroform
3. additiontreated with activated carbon
4. customevaporated to solids
5. customTrituration with ether gave crude product (8 g.)
6. customAn additional quantity of crude product (7.5 g.) crystallized from the aqueous phase which
7. customRecrystallization of the