HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 2-Hydroxyethyl 4-(4-chlorophenyl)pyrrole-2-carboxylate | HCID 13064273 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid | HCID 12897099 | — |
Reaction Steps
Crude 2-hydroxyethyl 4-(4-chlorophenyl)pyrrole-2-carboxylate (3 g.) was heated on a steam bath with potassium hydroxide (2 g.) in 25 ml. of water and 25 ml. of ethanol for 30 minutes. The balance of the ethanol was evaporated in vacuo, chloroform (25 ml.) was added and 4-(4-chlorophenyl)pyrrole-2-carboxylic acid (723 mg., m.p. 219°-222° C., ir(KBr): 3390, 3077 and 1695 cm.-1, m/e 221/223) recovered by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04282242 |
| Source dataset | uspto-grants-1981_08 |
| ORD ID | ord-beaab3b99dd7419685679af0097098d1 |
| Source note | uspto-grants-1981_08 |