Water → HCID 21162643, compound

Participants

Reaction Steps

116 ml of benzoyl chloride are added dropwise at a temperature of 25° C. to a suspension of 53 g of thiocarbohydrazide in 350 ml of pyridine with stirring and cooling. After addition, the mixture is stirred for a further 3 hours at room temperature and subsequently mixed with 6 liters of water. The precipitate obtained is separated, dissolved and reprecipitated from methanol/water and, after drying in air is mixed with 1.7 liters of boiling ethyl acetate and after cooling, is suction filtered and dried in the air. 112 g of 1,5-bisbenzoyl-thiocarbohydrazide which melts at 177° to 179° C. with decomposition are obtained.

Provenance & Evidence