Ethanol → HCID 178470423, compound

HRID 894110Notes

Reaction equation

HRID 894110 reaction equation
[CH3:1][C:2]1[C:6]([N+:7]([O-:9])=[O:8])=[C:5]([C:10]([OH:12])=[O:11])[NH:4][N:3]=1.S(=O)(=O)(O)O.[CH2:18](O)[CH3:19]>>[CH3:1][C:2]1[C:6]([N+:7]([O-:9])=[O:8])=[C:5]([C:10]([O:12][CH2:18][CH3:19])=[O:11])[NH:4][N:3]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 178434627HCID 178434627, compound

Product 1

HCID 178470423HCID 178470423, compound

Procedure

Esterification of 3-methyl-4-nitropyrazole-5-carboxylic acid was previously reported using ethanol and sulphuric acid at elevated temperatures. Attempts to repeat this procedure resulted in concomitant alkylation of the pyrazole nucleus. However, it was found that the desired ester could be obtained if this reaction was run at room temperature.

Sources & evidence

ORD record
ord-6aa384fd6194482288cefbfe6c147338
Source dataset
uspto-grants-1981_08
Patent number
US04282361

Reaction notes

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