Sodium Methoxide → HCID 178434373, compound

Participants

Reaction Steps

4-formylamino-3-methylpyrazole-5-carboxamide was cyclized in refluxing dimethylformamide with a catalytic amount of sodium methoxide to produce 7-hydroxy-3-methyl pyrazolo[4,3-d]pyrimidine in about an 80% yield. This reaction is illustrated as follows: ##STR5## Ring closure is thus achieved in this synthetic scheme by an intramolecular mechanism rather than an intermolecular mechanism as is the case in prior processes. This results in a much higher yield of product which is significantly purer than that produced by intermolecular routes.

Provenance & Evidence