Sodium Methoxide → HCID 178434373, compound

Participants

Reaction Steps

A solution of 4-formylamino-3-methylpyrazole-5-carboxamide (21.0 g, 125 mmol) and sodium methoxide (about 30 mg) in dimethylformamide (42 ml) was heated at reflux for 6 hrs. in an oil bath maintained at 160°. Some product crystallized in the hot reaction mixture. Cooling, filtering and washing with ethanol afforded (after drying in a vacuum oven at 120°) 15.03 g (80.2%) of a white solid, m.p. 340°.

Provenance & Evidence