HCID 178434627, compound → HCID 178434626, compound

Participants

Reaction Steps

In a method for synthesizing 7-alkylamino-3-methylpyrazolo[4,3-d]pyrimidines, including the steps of esterifying 3-methyl-4-nitropyrazole-5-carboxylic acid to ethyl 3-methyl-4-nitropyrazole-5-carboxylate, forming 3-methyl-4-nitropyrazole-5-carboxamide from ethyl 3-methyl-4-nitropyrazole-5-carboxylate, catalytically reducing and formylating ethyl 3-methyl-4-nitropyrazole-5-carboxamide to produce 4-formylamino-3-methylpyrazole-5-carboxamide, closing the ring of 4-formylamino-3-methylpyrazole-5-carboxamide to produce 3-methyl-7-hydroxypyrazolo[4,3-d]pyrimidine, chlorinating said 3-methyl-7-hydroxypyrazolo [4,3-d]pyrimidine to produce 7-chloro-3-methylpyrazolo-[4,3-d], and reacting said 7-chloro-3-methylpyrazolo[4,3-d]pyrimidine with an alkylamine to produce a 7-alkylamino-3-methylpyrazolo[4,3-d]pyrimidine:

Provenance & Evidence